The Last Dog is a dystopian novel set in the year 2086 in California by the Santa Cruz mountains. The majority of women are sterile. Dogs are the new children.

After the Unified World Pact of 2045, people lived in a state of peace and prosperity previously unknown in human history. The World Guild, the new global government, managed all the needs of humanity and the animals it loved.

Then in 2086, a security breach of Xavier Labs in Colorado and Zheng Industries in China released the deadly experimental agent XSKL435. Anyone outside was dead within minutes.

As statistics on the death toll are gathered from all over the world, Abby, the six-week-old dog-daughter of Bill and Teresa Maxwell, was one of only four known surviving canines. News services soon announce that the other three dogs had succumbed to the deadly poison. Abby was now the last dog.